The World Health Organization also reported that an average of 150,000 infants are born with sickle cell disease in Nigeria. The most commonly encountered abnormal hemoglobin genotypes among Nigerians include AS, AC, SC, and SS.
Is there any genotype like AC?
Genotype can simply be defined as the genetic constitution of an individual organism. The genotypes in humans are AA, AS, AC, SS. They refer to the hemoglobin gene constituents on the red blood cells. AC is rare, whereas AS and AC are abnormal.
Can AC genotype marry as genotype?
AC is rare whereas AS and AC are abnormal. Compatible genotypes for marriage are: AA marries an AA.
How bad is AC genotype?
Persons with hemoglobin C trait (Hb AC) are phenotypically normal, with no clinically evident limitations or symptoms, while those with hemoglobin C disease (Hb CC) may have a mild degree of hemolytic anemia, splenomegaly, and borderline anemia.
What is AC sickle cell?
You may have heard of sickle cell trait before, while not exactly the same, sickle cell trait and hemoglobin C trait are similar. What is hemoglobin C trait? Hemoglobin C trait (AC) is an inherited condition which affects the hemoglobin in your red blood cells. • Hemoglobin is a protein in red blood cells.
What type of blood group is AC?
There are four hemoglobin genotypes (hemoglobin pairs/formations) in humans: AA, AS, SS and AC (uncommon). SS and AC are the abnormal genotypes or the sickle cells. We all have a specific pair of these hemoglobin in our blood which we inherited from both parents.
Is CC genotype A Sickler?
Sickle cell anemia refers to an abnormal homozygote genotype (SS or CC), whereas sickle cell trait refers to heterozygote genotype AS or AC inducing mild disease.
Is AC a sickle cell carrier?
Related Links. People with hemoglobin C do not have Hemoglobin C disease or sickle cell disease. They cannot develop these diseases later in life. They can pass hemoglobin C trait to their children.
What is hemoglobin AC?
Hemoglobin C is an abnormal type of hemoglobin, the protein in red blood cells that carries oxygen. It is a type of hemoglobinopathy. The disease is caused by a problem with a gene called beta globin. The disease most often occurs in African Americans.
Which genotype has the strongest immunity?
The GG genotype of SP induced stronger immune responses than those of the other two genotypes in the pattern recognition molecule and immune-responsive effector pathways. These findings demonstrated the population variations of RSV during the circulation between the vector insect and host plant.
What is hemoglobin C trait with pregnancy?
Hemoglobin C trait is when a baby inherited one gene for hemoglobin A from one parent and one gene for hemoglobin C from the other parent. People with hemoglobin C trait are not sick.
What is SC and CC in genotype?
A third allele (C) results in the following genotypes and phenotypes: AC is normal but susceptible, SC has mild anemia and CC is normal and resistant to malaria. The following approximate fitnesses have been assigned to these genotypes: Genotype.
Can SC genotype live long?
Patients with Hb SC disease live longer than patients with Hb SS and have fewer painful episodes, but this disorder is associated with considerable morbidity and mortality, especially after age 30. In the United States the median life span for men is 60 years and for women 68 years.