What does a duplicated chromosome mean?

Chromosome duplication: Part of a chromosome in duplicate. A particular kind of mutation involving the production of one or more copies of any piece of DNA, including sometimes a gene or even an entire chromosome. A duplication is the opposite of a deletion.

What happens if you have a duplicated chromosome?

In chromosomal duplications, extra copies of a chromosomal region are formed, resulting in different copy numbers of genes within that area of the chromosome.

What disease is caused by a duplicated chromosome?

Potocki-Lupski syndrome is a condition that results from having an extra copy (duplication ) of a small piece of chromosome 17 in each cell. The duplication occurs on the short (p) arm of the chromosome at a position designated p11. 2.

Is chromosomal duplication harmful?

Gene duplications are an essential source of genetic novelty that can lead to evolutionary innovation. Duplication creates genetic redundancy, where the second copy of the gene is often free from selective pressure—that is, mutations of it have no deleterious effects to its host organism.

What are the symptoms of duplication?

What are the signs and symptoms of MECP2 duplication syndrome?

  • Hypotonia (low muscle tone), which is usually apparent in infancy.
  • Delayed development of milestones.
  • Moderate to severe intellectual disability.
  • Inability to talk, or limited speech ability that may be lost with age.

Is duplication inherited?

2 duplications are not inherited. Instead, they occur as random events during the formation of reproductive cells (eggs and sperm) or in early fetal development.

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