The genotype of HCV for diagnosis is mostly determined by sequencing of genomic nucleotide sequence or by kit-based assays which employ complementary probes to report genotype present in a specimen.
Which HCV genotype is most common?
HCV subtypes 1a and 1b are the most common genotypes in the United States (Fig. 3) (145). These subtypes also are predominant in Europe (35, 82, 91).
Why is HCV genotyping important?
Genotyping is more significant for planning of HCV treatment period and helps to cure HCV infections. For the quantification and identification of hepatitis C virus-ribonucleic acid, many molecular techniques are performed; the most significant are HCV ELISA, quantitative HCV-RNA PCR and recombinant immunoblot assay.
Who HCV genotype distribution?
Globally, HCV genotype 1 is the most prevalent worldwide (49.1%), followed by genotype 3 (17.9%), 4 (16.8%) and 2 (11.0%), while genotypes 5 and 6 are responsible for the remaining < 5% .
Can HCV genotype change?
Six major genotypes of the hepatitis C virus (HCV) have been described; it is assumed to be uncommon for genotypes to change in chronically infected individuals.
What is Hep C genotype 1b?
Conclusion: HCV genotype 1b is associated with a statistically significant higher risk of developing HCC. Patients with cirrhosis that are infected with this genotype require more intensive surveillance for the early detection and aggressive management of neoplasia.
Which HCV genotype is easiest to treat?
In the United States, hepatitis C genotype 3 is less commonly contracted than genotype 1, but genotype 3 is also harder to treat.
Genotype 3 has been found to respond better to newer drug combinations, including:
- glecaprevir-pibrentasvir (Mavyret)
- sofosbuvir-velpatasvir (Epclusa)
- daclatasvir-sofosbuvir (Sovaldi)
What is a genotype of a virus?
Genotypes of HCV are genetically distinct groups of the virus that have arisen during its evolution.(1) Approximately 75% of Americans with HCV have genotype 1 of the virus (subtypes 1a or 1b), and 20-25% have genotypes 2 or 3, with small numbers of patients infected with genotypes 4, 5, or 6.(2) Most patients with HCV …
What is the meaning of genotypes?
In a broad sense, the term “genotype” refers to the genetic makeup of an organism; in other words, it describes an organism’s complete set of genes. … Humans are diploid organisms, which means that they have two alleles at each genetic position, or locus, with one allele inherited from each parent.
How long does Hep C genotype test take?
Rapid anti-HCV tests are available in some health clinics and the results of these tests are available in 20 to 30 minutes. What does a non-reactive HCV antibody test result mean? A non-reactive or negative antibody test means that you are not currently infected with the hepatitis C virus.
How many HBV genotypes are there?
The virus has been classified according to 8 genotypes (A-H) based on sequence divergence. Most genotypes have specific geographic distributions; genotypes A and D are prevalent in Western Europe and North America, and genotypes B and C are prevalent in East Asia and Oceania.