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Allele frequency refers to how common an allele is in a population. It is determined by counting how many times the allele appears in the population then dividing by the total number of copies of the gene.

## How do you calculate allele frequency?

An allele frequency is calculated by dividing the number of times the allele of interest is observed in a population by the total number of copies of all the alleles at that particular genetic locus in the population. Allele frequencies can be represented as a decimal, a percentage, or a fraction.

## What is the allele frequency of the A allele?

The frequency of the “a” allele. Answer: The frequency of aa is 36%, which means that q^{2} = 0.36, by definition. If q^{2} = 0.36, then q = 0.6, again by definition.

## How do you calculate the change in allele frequencies?

We can also describe the change in allele frequency between generations (Dp) as: Dp = (p_{t}_{+}_{1}) – (p_{t}).

## How does Hardy-Weinberg calculate allele frequencies?

The Hardy-Weinberg equation used to determine genotype frequencies is: p^{2} + 2pq + q^{2} = 1. Where ‘p^{2}‘ represents the frequency of the homozygous dominant genotype (AA), ‘2pq’ the frequency of the heterozygous genotype (Aa) and ‘q^{2}‘ the frequency of the homozygous recessive genotype (aa).

## What is Q 2 Hardy-Weinberg?

In the equation, p^{2} represents the frequency of the homozygous genotype AA, q^{2} represents the frequency of the homozygous genotype aa, and 2pq represents the frequency of the heterozygous genotype Aa. In addition, the sum of the allele frequencies for all the alleles at the locus must be 1, so p + q = 1.

## How do you find the minor allele frequency?

Find MAF/MinorAlleleCount link. MAF/MinorAlleleCount: C=0.1506/754 (1000 Genomes); where C is the minor allele for that particular locus; 0.1506 is the frequency of the C allele (MAF), i.e. 15% within the 1000 Genomes database; and 754 is the number of times this SNP has been observed in the population of the study.

## How do you find allele frequency from phenotype frequency?

Allele Frequency

- Allele frequency is most commonly calculated using the Hardy-Weinberg equation, which describes the relationship between two alleles within a population. …
- To find the number of alleles in a given population, you must look at all the phenotypes present. …
- 1 = p
^{2}+ 2pq + q^{2}

## How do you calculate carrier frequency?

The carrier frequency can then be calculated as 2X99/100×1/100 which approximates to 1 in 50. Thus a rough approximation of the carrier frequency can be obtained by doubling the square root of the disease incidence. For an X-linked disorder the frequency of affected males equals the frequency of the mutant allele, q.