What would happen to a chromosome without telomeres?

Colchicine, Mitosis, and Karyotypes. The alkaloid drug, colchicine, extracted from the corm of the autumn crocus (Colchicum autumnale), arrests mitosis in metaphase by interfering with the formation of spindle fibrils, thereby retarding the division of the centromeres and preventing division of the centrioles.

What happens if the telomeres are removed?

When telomeres are short or dysfunctional, this results in apoptosis or a permanent cell cycle arrest [177]. The mutant telomerase and telomere genes lead to shortening of telomeres and may cause age-related disease, such as degenerative organ failure, and a cancer-prone state [177].

What would happen to chromosome ends in the absence of telomerase?

These results demonstrated that telomere loss in telomerase-deficient cells lacking cell cycle regulation results in chromosome rearrangements leading to cancer.

Why do chromosomes need telomeres?

Their job is to stop the ends of chromosomes from fraying or sticking to each other, much like the plastic tips on the ends of shoelaces. Telomeres also play an important role in making sure our DNA gets copied properly when cells divide.

Why is telomerase necessary during the replication of eukaryotic chromosomes?

Why is telomerase necessary during the replication of eukaryotic chromosomes? during DNA replicati, ends of molecules lack ends… primase doesn’t reach. telomerase adds ends, so they won’t deteriorate.

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What would happen if telomerase stopped working in a cell in which it normally functions at high levels?

What would happen if telomerase stopped working in a cell in which it normally functions at high levels? … The cell would eventually die as the DNA continued to shorten.

Why are telomeres important in DNA replication?

The ends of the linear chromosomes are known as telomeres: repetitive sequences that code for no particular gene. These telomeres protect the important genes from being deleted as cells divide and as DNA strands shorten during replication. In humans, a six base pair sequence, TTAGGG, is repeated 100 to 1000 times.

What is a telomere and what does it do?

A telomere is a repeating DNA sequence (for example, TTAGGG) at the end of the body’s chromosomes. The telomere can reach a length of 15,000 base pairs. Telomeres function by preventing chromosomes from losing base pair sequences at their ends. They also stop chromosomes from fusing to each other.