Spindle depolymeriation is caused by Colchicine.
Which of the following is used as a mitotic poison?
All of these chemicals, mustard gas and azides, cyanides, and colchicines are mitotic poisons.
Is a spindle poison?
A spindle poison, also known as a spindle toxin, is a poison that disrupts cell division by affecting the protein threads that connect the centromere regions of chromosomes, known as spindles.
Is colchicine a spindle poison?
Colchicine, the classic antimitotic poison, disrupts cell division by preventing proper assembly of microtubules in the mitotic spindle. Colchicine is known to act by binding to tubulin, the heterodimeric subunit of microtubules.
Which of the following produces the mitotic spindle?
The centrosome determines the shape of the cell as well as the mitotic spindle apparatus. In eukaryotic cells, polymerization of microtubules from alpha and beta tubulin is initiated at the centrosome to form the mitotic spindle and the structure for cytokinesis.
Which of the following is true for the mitotic spindle?
The correct answer is (c); it is composed of microtubules, which help separate the chromosomes to opposite poles of the cell.
Is mustard gas mitotic poison?
– Azides and cyanides are one of them. Enzyme ribonuclease acts at prophase stage. Mustard gas causes agglutination of chromosome material and is the effective mitotic poison.
What is meant by mitotic spindle?
In cell biology, the spindle apparatus (or mitotic spindle) refers to the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells.
Which phase is initiation of assembly of mitotic spindle?
Answer-(4) Initiation of assembly of mitotic spindle occurs during Prophase of mitosis.
Why is colchicine called mitotic poison?
Mechanistically, colchicine inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules. In another sense, availability of tubulin is necessary to mitosis; hence colchicine effectively works as a “mitotic poison” or spindle poison.
Which chemical is used to spindle breakage?
Vincristine and vinblastine are most commonly used, with new drugs such as teniposide and vinorelbine being used in human medicine.
Does colchicine affect mitosis?
Colchicine exerts a toxic effect on living cells which commonly results in the arrest of the process of mitosis at an early stage, usually the metaphase, with the production of bizarre and abnormal nuclear configurations, and frequently leading to cell death.
What do mitotic inhibitors do?
A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer.