Which disorder is caused by partial deletion of the short arm of chromosome No 4?
Wolf-Hirschorn syndrome (4p-syndrome) is a chromosomal disorder caused by a partial deletion of part of the short arm of chromosome 4.
What is a chromosome 4 disorder?
Chromosome 4, Trisomy 4p is a rare chromosomal disorder in which all or a portion of the short arm (p) of chromosome 4 appears three times (trisomy) rather than twice in cells of the body. Associated symptoms and physical findings may vary greatly in range and severity from case to case.
What happens if you are missing chromosome 4?
When any part of a chromosome is missing, it can damage normal development. The deleted chromosome 4 causes the features of Wolf-Hirschhorn, including facial features like wide-set eyes, a distinct bump on the forehead, a broad nose, and low-set ears.
What is short arm syndrome?
Hypochrondroplasia is a genetic disorder characterized by small stature and disproportionately short arms, legs, hands, and feet (short-limbed dwarfism). Short stature often is not recognized until early to mid childhood or, in some cases, as late as adulthood.
What causes Turner syndrome?
Turner syndrome occurs when part or all of an X chromosome is missing from most or all of the cells in a girl’s body. A girl normally receives one X chromosome from each parent. The error that leads to the missing chromosome appears to happen during the formation of the egg or sperm.
What is Hirschhorn syndrome?
Summary. Listen. Wolf-Hirschhorn syndrome (WHS) is a genetic disorder that affects many parts of the body. The major features include a characteristic facial appearance, delayed growth and development, intellectual disability , low muscle tone ( hypotonia ), and seizures .